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Chemical structure of HBT1

GC69208

HBT1

Also known as 2-[[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

HBT1 is an effective enhancer of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPA-R)· HBT1 binds to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner, specifically at S518· HBT1 did not show significant bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons

ChemicalCAS489408-02-8MW386.39FormulaC16H17F3N4O2S
CAS number
489408-02-8
Molecular weight
386.39
Formula
C16H17F3N4O2S
Solubility
DMSO ： 250 mg/mL (647·01 mM; Need ultrasonic)
InChIKey
PHLXSNIEQIKENK-UHFFFAOYSA-N
Catalogue number
GC69208
Brand
GLPBIO
Computed properties PubChem CID 1222102 · XLogP 3.2 · TPSA 118 Ų · H-bond donors 2
XLogP
3.2
TPSA
118 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
26

SMILES CC1=CC(=NN1CC(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)C(F)(F)F

Computed descriptors from PubChem (CID 1222102), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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