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Chemical structure of GW768505A free base

GC69203

GW768505A free base

Also known as 1-[4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea

GW768505A free base is an efficient dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 value of 7·81 for the action on VEGFR2· GW768505A free base has anti-angiogenic activity

ChemicalCAS501693-25-0MW537.47FormulaC27H19F4N5O3
CAS number
501693-25-0
Molecular weight
537.47
Formula
C27H19F4N5O3
InChIKey
FGZIONRFHVNRJB-UHFFFAOYSA-N
Catalogue number
GC69203
Brand
GLPBIO
Computed properties PubChem CID 5326956 · XLogP 5.4 · TPSA 115 Ų · H-bond donors 3
XLogP
5.4
TPSA
115 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
5
Heavy atoms
39

SMILES COC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3O2)N)C4=CC=C(C=C4)NC(=O)NC5=C(C=CC(=C5)C(F)(F)F)F

Computed descriptors from PubChem (CID 5326956), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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