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Chemical structure of Gcase activator 2

GC69155

Gcase activator 2

Also known as 1-[4-[2-(4-methoxyphenyl)-5-methylpyrrolo[2,3-b]pyrazin-6-yl]piperidin-1-yl]ethanone

Gcase activator 2 (compound 14) is a pyrrolo[2,3-b]pyridine and a beta-glucocerebrosidase (Gcase) activator with an EC50 of 3·8 μM· Gcase activator 2 induces Gcase dimerization (including k-type and v-type)· Gcase activator 2 has low metabolic clearance in humans and mice

ChemicalCAS2759897-35-1MW364.44FormulaC21H24N4O2
CAS number
2759897-35-1
Molecular weight
364.44
Formula
C21H24N4O2
InChIKey
HEAGFUMRBLFGAD-UHFFFAOYSA-N
Catalogue number
GC69155
Brand
GLPBIO
Computed properties PubChem CID 155289224 · XLogP 2 · TPSA 60.3 Ų · H-bond donors 0
XLogP
2
TPSA
60.3 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
27

SMILES CC(=O)N1CCC(CC1)C2=CC3=NC(=CN=C3N2C)C4=CC=C(C=C4)OC

Computed descriptors from PubChem (CID 155289224), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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