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Chemical structure of EM127

GC69055

EM127

Also known as N-[1-(2-chloroacetyl)piperidin-4-yl]-5-cyclopropyl-1,2-oxazole-3-carboxamide

EM127 (compound 11c) is a highly selective, high-affinity, and site-specific covalent inhibitor of SMYD3 (KD=13 μM)· EM127 effectively inhibits ERK1/2 phosphorylation and reduces transcriptional regulation of SMYD3 target genes· EM127 can effectively and persistently weaken the activity of methyltransferases· EM127 can be used for cancer research, especially in SMYD3-positive tumors

ChemicalCAS1886879-71-5MW311.76FormulaC14H18ClN3O3
CAS number
1886879-71-5
Molecular weight
311.76
Formula
C14H18ClN3O3
InChIKey
OENTXAYVUCLRJQ-UHFFFAOYSA-N
Catalogue number
GC69055
Brand
GLPBIO
Computed properties PubChem CID 118949515 · XLogP 1.2 · TPSA 75.4 Ų · H-bond donors 1
XLogP
1.2
TPSA
75.4 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
21

SMILES C1CC1C2=CC(=NO2)C(=O)NC3CCN(CC3)C(=O)CCl

Computed descriptors from PubChem (CID 118949515), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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