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Chemical structure of E1231

GC69033

E1231

Also known as 1-[4-[2-(5-methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl]ethanone

E1231 is an orally effective activator of Sirtuin 1 (SIRT1) with an EC50 of 0·83 μM, which can regulate cholesterol and lipid metabolism· E1231 interacts with both SIRT1 and liver X receptor-α (LXRα) and increases the expression of ATP-binding cassette transporter A1 (ABCA1)· E1231 also reduces the formation of atherosclerotic plaques in ApoE-/- mouse models· E1231 can be used for research on diseases related to cholesterol and lipid disorders

ChemicalCAS1031195-19-3MW363.41FormulaC21H21N3O3
CAS number
1031195-19-3
Molecular weight
363.41
Formula
C21H21N3O3
Solubility
DMSO ： 100 mg/mL (275·17 mM; Need ultrasonic)
InChIKey
ZQJTYRXKAZFWPK-UHFFFAOYSA-N
Catalogue number
GC69033
Brand
GLPBIO
Computed properties PubChem CID 24980435 · XLogP 2.1 · TPSA 66.7 Ų · H-bond donors 0
XLogP
2.1
TPSA
66.7 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
27

SMILES CC1=CC=C(O1)C2=NC3=CC=CC=C3C(=C2)C(=O)N4CCN(CC4)C(=O)C

Computed descriptors from PubChem (CID 24980435), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.