Loading...
Chemical structure of Dersimelagon

GC68965

Dersimelagon

Also known as 1-[2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl]piperidine-4-carboxylic acid

Dersimelagon (MT-7117) is a selective melanocortin 1 receptor (MC1R) agonist with oral activity· Its EC50 values for human (h), crab-eating macaque (cm), mouse (m), and rat (r) MC1R are 8·16, 3·91, 1·14, and 0·251 nM respectively· Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2·26 and 32·9 nM respectively· It can be used in research on skin pigmentation [1][2]

ChemicalCAS1835256-48-8MW675.75FormulaC36H45F4N3O5
CAS number
1835256-48-8
Molecular weight
675.75
Formula
C36H45F4N3O5
Solubility
DMSO ： 25 mg/mL (37·00 mM; ultrasonic and warming and heat to 60°C)
InChIKey
MUNWOYRHJPWQNE-GMFUQMJFSA-N
Catalogue number
GC68965
Brand
GLPBIO
Computed properties PubChem CID 126736894 · XLogP 3.1 · TPSA 82.6 Ų · H-bond donors 1
XLogP
3.1
TPSA
82.6 Ų
H-bond donors
1
H-bond acceptors
11
Rotatable bonds
9
Heavy atoms
48

SMILES COC[C@H]1CN(C[C@@H]1C2=C(C=C(C=C2)C(F)(F)F)N3CCC(CC3)C(=O)O)C(=O)[C@@]4(CN(C[C@H]4C5=CC=C(C=C5)OC)C6CCCC6)F

Computed descriptors from PubChem (CID 126736894), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.