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Chemical structure of Darizmetinib

GC68937

Darizmetinib

Also known as N-[2,6-difluoro-3-(5-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl]propane-1-sulfonamide

Darizmetinib is an inhibitor of mitogen-activated protein kinase kinase (MAP2K)

ChemicalCAS2369583-33-3MW457.45FormulaC21H17F2N5O3S
CAS number
2369583-33-3
Molecular weight
457.45
Formula
C21H17F2N5O3S
InChIKey
WBNMARNYIFMNEP-UHFFFAOYSA-N
Catalogue number
GC68937
Brand
GLPBIO
Computed properties PubChem CID 139369660 · XLogP 3.1 · TPSA 126 Ų · H-bond donors 2
XLogP
3.1
TPSA
126 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
32

SMILES CCCS(=O)(=O)NC1=C(C=CC(=C1F)C(=O)C2=C3C=C(C=NC3=NN2)C4=CC=NC=C4)F

Computed descriptors from PubChem (CID 139369660), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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