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Chemical structure of Capmatinib Hydrochloride

GC68828

Capmatinib Hydrochloride

Also listed as Capmatinib dihydrochloride hydrate

Capmatinib (INC280; INCB28060) dihydrochloride hydrate is an effective, orally active, selective, ATP-competitive c-Met kinase inhibitor (IC50=0·13 nM)· Capmatinib dihydrochloride hydrate can inhibit the phosphorylation of c-MET and downstream effectors such as ERK1/2, AKT, FAK, GAB1 and STAT3/5 in the c-MET pathway· Capmatinib dihydrochloride hydrate effectively inhibits proliferation and migration of c-Met-dependent tumor cells and induces apoptosis· It exhibits anti-tumor activity in mouse models of cancer· Capmatinib dihydrochloride hydrate is mainly metabolized by CYP3A4 and aldehyde oxidase

ChemicalCAS1865733-40-9MW503.36FormulaC23H21Cl2FN6O2
CAS number
1865733-40-9
Molecular weight
503.36
Formula
C23H21Cl2FN6O2
Solubility
DMSO ： 20·83 mg/mL (41·38 mM; ultrasonic and warming and heat to 60°C)
InChIKey
COWBUPJEEDYWKD-UHFFFAOYSA-N
Catalogue number
GC68828
Brand
GLPBIO
Computed properties PubChem CID 122201352 · TPSA 86.1 Ų · H-bond donors 4 · H-bond acceptors 7
TPSA
86.1 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
34

SMILES CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F.O.Cl.Cl

Computed descriptors from PubChem (CID 122201352), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.