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Chemical structure of Butyzamide

GC68819

Butyzamide

Also known as (E)-3-[2,6-dichloro-4-[[4-[3-(2,2-dimethyl-1-propoxypropyl)-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid

Butyzamide is an orally effective Mpl activator, where Mpl is a receptor for thrombopoietin (TPO) involved in platelet production· Butyzamide increases the phosphorylation levels of JAK2, STAT3, STAT5 and MAPK· In mouse xenograft experiments, Butyzamide increases human platelet levels

ChemicalCAS1110767-45-7MW591.55FormulaC29H32Cl2N2O5S
CAS number
1110767-45-7
Molecular weight
591.55
Formula
C29H32Cl2N2O5S
Solubility
DMSO ： 100 mg/mL (169·05 mM; Need ultrasonic)
InChIKey
BBEZGQPYGPBSLA-FOWTUZBSSA-N
Catalogue number
GC68819
Brand
GLPBIO
Computed properties PubChem CID 44602781 · XLogP 7.6 · TPSA 126 Ų · H-bond donors 2
XLogP
7.6
TPSA
126 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
11
Heavy atoms
39

SMILES CCCOC(C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(C(=C3)Cl)/C=C(\C)/C(=O)O)Cl)C(C)(C)C

Computed descriptors from PubChem (CID 44602781), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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