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Chemical structure of BMS-984923

GC68784

BMS-984923

Also known as (4R,5R)-5-(2-chlorophenyl)-4-[5-(2-phenylethynyl)-3-pyridinyl]-1,3-oxazolidin-2-one

BMS-984923 is an effective mGluR5 negative allosteric modulator with good affinity (Ki = 0·6 nM), oral bioavailability, and blood-brain barrier permeability· It can effectively inhibit the interaction between PrPC-mGluR5 and suppress pathological Aβo signals without affecting physiological glutamate signaling

ChemicalCAS1375752-78-5MW374.82FormulaC22H15ClN2O2
CAS number
1375752-78-5
Molecular weight
374.82
Formula
C22H15ClN2O2
Solubility
DMSO ： 50 mg/mL (133·40 mM; Need ultrasonic)
InChIKey
IAYVUQJOKDFLAL-NHCUHLMSSA-N
Catalogue number
GC68784
Brand
GLPBIO
Computed properties PubChem CID 69084898 · XLogP 4.4 · TPSA 51.2 Ų · H-bond donors 1
XLogP
4.4
TPSA
51.2 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
27

SMILES C1=CC=C(C=C1)C#CC2=CC(=CN=C2)[C@@H]3[C@H](OC(=O)N3)C4=CC=CC=C4Cl

Computed descriptors from PubChem (CID 69084898), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.