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Chemical structure of BAY-747

GC68741

BAY-747

Also known as N-[(2S)-2-amino-2-methylbutyl]-8-[(2,6-difluorophenyl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide

BAY-747 (BAY 1165747) is an orally effective and brain-penetrant soluble guanylate cyclase (sGC) stimulator· BAY-747 reverses L-NAME-induced memory impairment and enhances cognition in rats· It also lowers conscious blood pressure in both normotensive and spontaneously hypertensive rats (SHR)· Additionally, BAY-747 improves skeletal muscle function associated with Duchenne muscular dystrophy (DMD) in the mdx/mTRG2 mouse model

ChemicalCAS1609342-18-8MW416.46FormulaC22H26F2N4O2
CAS number
1609342-18-8
Molecular weight
416.46
Formula
C22H26F2N4O2
InChIKey
MITNUFZPBQIMAT-QFIPXVFZSA-N
Catalogue number
GC68741
Brand
GLPBIO
Computed properties PubChem CID 90132548 · XLogP 4 · TPSA 81.7 Ų · H-bond donors 2
XLogP
4
TPSA
81.7 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
30

SMILES CC[C@@](C)(CNC(=O)C1=C(N=C2N1C=C(C=C2OCC3=C(C=CC=C3F)F)C)C)N

Computed descriptors from PubChem (CID 90132548), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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