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Chemical structure of ASR-490

GC68701

ASR-490

Also known as [(1S,2R,6S,7S,9R,11S,12S,15R,16S)-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-3-oxo-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-6-yl] pyridine-2-carboxylate

ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling· ASR-490 overcomes the overexpression of Notch1 and inhibits the growth of HCT/Notch1 transfectants· In xenograft mice, ASR-490 suppresses tumor growth in control (pCMV/HCT116) and Notch1/HCT116 groups

ChemicalCAS2690312-67-3MW575.69FormulaC34H41NO7
CAS number
2690312-67-3
Molecular weight
575.69
Formula
C34H41NO7
Solubility
DMSO ： 25 mg/mL (43·43 mM; Need ultrasonic)
InChIKey
VLOZRPFAQLWDLI-RJMVMCCISA-N
Catalogue number
GC68701
Brand
GLPBIO
Computed properties PubChem CID 156831801 · XLogP 5.3 · TPSA 115 Ų · H-bond donors 1
XLogP
5.3
TPSA
115 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
42

SMILES CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6OC(=O)C7=CC=CC=N7)C)O5)C)CO

Computed descriptors from PubChem (CID 156831801), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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