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Chemical structure of Amgen-23

GC68650

Amgen-23

Also known as (2R,4S)-1-[2-[4-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino]phenyl]ethyl]-2-(hydroxymethyl)piperidin-4-ol

Amgen-23 (compound 23) is an effective inhibitor of sphingosine kinase (SPHK), with IC50 values of 20 nM and 1·6 μM for SPHK1 and SPHK2, respectively· Amgen-23 can be used in cancer research

ChemicalCAS1448706-15-7MW478.43FormulaC23H25Cl2N3O2S
CAS number
1448706-15-7
Molecular weight
478.43
Formula
C23H25Cl2N3O2S
Solubility
DMSO ： 100 mg/mL (209·02 mM; Need ultrasonic)
InChIKey
SQJKFWCRPARYPY-MOPGFXCFSA-N
Catalogue number
GC68650
Brand
GLPBIO
Computed properties PubChem CID 71627420 · XLogP 5.3 · TPSA 96.9 Ų · H-bond donors 3
XLogP
5.3
TPSA
96.9 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
31

SMILES C1CN([C@H](C[C@H]1O)CO)CCC2=CC=C(C=C2)NC3=NC(=CS3)C4=CC(=C(C=C4)Cl)Cl

Computed descriptors from PubChem (CID 71627420), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.