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Chemical structure of ABC1183

GC68592

ABC1183

Also known as 4-[4-amino-2-(4-methylanilino)-1,3-thiazole-5-carbonyl]benzonitrile

ABC1183 is a selective dual inhibitor of GSK3 and CDK9 with oral activity· Its IC50 values for GSK3β, GSK3α, and CDK9/cyclin T1 are 657 nM, 327 nM, and 321 nM respectively· ABC1183 has anti-inflammatory properties as well as anti-tumor activity

ChemicalCAS1042735-18-1MW334.39FormulaC18H14N4OS
CAS number
1042735-18-1
Molecular weight
334.39
Formula
C18H14N4OS
Solubility
DMSO ： 125 mg/mL (373·82 mM; Need ultrasonic)
InChIKey
CUDLEXBIVZPJBU-UHFFFAOYSA-N
Catalogue number
GC68592
Brand
GLPBIO
Computed properties PubChem CID 134500787 · XLogP 4.8 · TPSA 120 Ų · H-bond donors 2
XLogP
4.8
TPSA
120 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
24

SMILES CC1=CC=C(C=C1)NC2=NC(=C(S2)C(=O)C3=CC=C(C=C3)C#N)N

Computed descriptors from PubChem (CID 134500787), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.