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Chemical structure of A-908292

GC68587

A-908292

Also known as methyl N-[(2S)-4-[2-(4-propan-2-yloxyphenoxy)-1,3-thiazol-5-yl]but-3-yn-2-yl]carbamate

A-908292 is an effective and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 value of 23 nM for hACC2· A-908292 can be used in the study of fatty acid metabolism

ChemicalCAS903886-95-3MW360.43FormulaC18H20N2O4S
CAS number
903886-95-3
Molecular weight
360.43
Formula
C18H20N2O4S
Solubility
DMSO : 50 mg/mL (138·72 mM; ultrasonic and warming and heat to 60°C)
InChIKey
OLMPAYQFDVALIH-ZDUSSCGKSA-N
Catalogue number
GC68587
Brand
GLPBIO
Computed properties PubChem CID 11681998 · XLogP 3.9 · TPSA 97.9 Ų · H-bond donors 1
XLogP
3.9
TPSA
97.9 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
25

SMILES C[C@@H](C#CC1=CN=C(S1)OC2=CC=C(C=C2)OC(C)C)NC(=O)OC

Computed descriptors from PubChem (CID 11681998), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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