GC68503
20S Proteasome activator 1
Also known as 3-(2-chlorophenothiazin-10-yl)-N,N-bis(4-fluorophenyl)propanamide
20S Proteasome activator 1 is an effective activator of the 20S protease, with IC50 values of 0·3 μM, 0·7 μM and 1·8 μM for trypsin-like sites, chymotrypsin-like sites and caspase-like sites respectively· It can be translated in cellular systems to prevent accumulation of pathogenic A53T mutant alpha-synuclein· 20S Proteasome activator 1 can be used for research on neurodegenerative diseases
ChemicalCAS2761578-18-9MW492.97FormulaC27H19ClF2N2OS
- CAS number
- 2761578-18-9
- Molecular weight
- 492.97
- Formula
- C27H19ClF2N2OS
- Solubility
- DMSO ： 100 mg/mL (202·85 mM; Need ultrasonic)
- InChIKey
- ZFFNQHQEQWDWBM-UHFFFAOYSA-N
- Catalogue number
- GC68503
- Brand
- GLPBIO
Computed properties PubChem CID 164886633 · XLogP 7.5 · TPSA 48.9 Ų · H-bond donors 0
- XLogP
- 7.5
- TPSA
- 48.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Rotatable bonds
- 5
- Heavy atoms
- 34
SMILES C1=CC=C2C(=C1)N(C3=C(S2)C=CC(=C3)Cl)CCC(=O)N(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
Computed descriptors from PubChem (CID 164886633), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il