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Chemical structure of Phthalimide-PEG3-C2-OTs

GC67186

Phthalimide-PEG3-C2-OTs

Also known as 2-[2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition· Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs· PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein· PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

ChemicalCAS382162-12-1MW477.53FormulaC23H27NO8S
CAS number
382162-12-1
Molecular weight
477.53
Formula
C23H27NO8S
InChIKey
LWPAUABODZZAIN-UHFFFAOYSA-N
Catalogue number
GC67186
Brand
GLPBIO
Computed properties PubChem CID 10961802 · XLogP 1.8 · TPSA 117 Ų · H-bond donors 0
XLogP
1.8
TPSA
117 Ų
H-bond donors
0
H-bond acceptors
8
Rotatable bonds
14
Heavy atoms
33

SMILES CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCN2C(=O)C3=CC=CC=C3C2=O

Computed descriptors from PubChem (CID 10961802), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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