Loading...
Chemical structure of DVD-445

GC66477

DVD-445

Also known as 2-[[2-(tert-butylamino)-1-(4-fluorophenyl)-2-oxoethyl]-methylamino]ethyl (E)-4-(4-fluorophenyl)-4-oxobut-2-enoate

DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0·60 μM for rat TrxR1· DVD-445 has good anticancer application

ChemicalCAS2375846-41-4MW458.5FormulaC25H28F2N2O4
CAS number
2375846-41-4
Molecular weight
458.5
Formula
C25H28F2N2O4
Solubility
DMSO ： 100 mg/mL (218·10 mM; ultrasonic and warming and heat to 60°C)
InChIKey
RJGWWNVHLMPYEN-BUHFOSPRSA-N
Catalogue number
GC66477
Brand
GLPBIO
Computed properties PubChem CID 139035059 · XLogP 4 · TPSA 75.7 Ų · H-bond donors 1
XLogP
4
TPSA
75.7 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
11
Heavy atoms
33

SMILES CC(C)(C)NC(=O)C(C1=CC=C(C=C1)F)N(C)CCOC(=O)/C=C/C(=O)C2=CC=C(C=C2)F

Computed descriptors from PubChem (CID 139035059), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.