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Chemical structure of ESI-08

GC66473

ESI-08

Also known as 4-cyclohexyl-2-[(2,5-dimethylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidine-5-carbonitrile

ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8·4 μM) activity· ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation

ChemicalCAS301177-43-5MW353.48FormulaC20H23N3OS
CAS number
301177-43-5
Molecular weight
353.48
Formula
C20H23N3OS
Solubility
DMSO ： 100 mg/mL (282·90 mM; ultrasonic and warming and heat to 60°C)
InChIKey
LSHOSZQLVLPEGG-UHFFFAOYSA-N
Catalogue number
GC66473
Brand
GLPBIO
Computed properties PubChem CID 135473051 · XLogP 4.5 · TPSA 90.6 Ų · H-bond donors 1
XLogP
4.5
TPSA
90.6 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
25

SMILES CC1=CC(=C(C=C1)C)CSC2=NC(=C(C(=O)N2)C#N)C3CCCCC3

Computed descriptors from PubChem (CID 135473051), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
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