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Chemical structure of Osilodrostat phosphate

GC66454

Osilodrostat phosphate

Also known as 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile;phosphoric acid

Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM· Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0·7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively· Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis· Osilodrostat phosphate has blood pressure lowering ability· Osilodrostat phosphate can be used for research of Cushing syndrome (CS)

ChemicalCAS1315449-72-9MW325.23FormulaC13H13FN3O4P
CAS number
1315449-72-9
Molecular weight
325.23
Formula
C13H13FN3O4P
Solubility
H2O ： ≥ 200 mg/mL (614·95 mM)
InChIKey
FMCPYRDGUZBOJZ-BTQNPOSSSA-N
Catalogue number
GC66454
Brand
GLPBIO
Computed properties PubChem CID 71009737 · TPSA 119 Ų · H-bond donors 3 · H-bond acceptors 7
TPSA
119 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
1
Heavy atoms
22

SMILES C1CC2=CN=CN2[C@H]1C3=C(C=C(C=C3)C#N)F.OP(=O)(O)O

Computed descriptors from PubChem (CID 71009737), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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