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Chemical structure of MPP+-d3(iodide)

GC66401

MPP+-d3(iodide)

Also known as 4-phenyl-1-(trideuteriomethyl)pyridin-1-ium iodide

MPP+-d3(iodide) is deuterium labeled MPP+ (iodide)· MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra· MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain· MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)

ChemicalCAS207556-07-8MW300.15FormulaC12H9D3IN
CAS number
207556-07-8
Molecular weight
300.15
Formula
C12H9D3IN
Solubility
DMSO ： 100 mg/mL (333·17 mM; Need ultrasonic); DMSO ： 100 mg/mL (333·17 mM; Need ultrasonic)
InChIKey
RFDFRDXIIKROAI-NIIDSAIPSA-M
Catalogue number
GC66401
Brand
GLPBIO
Computed properties PubChem CID 16212321 · TPSA 3.9 Ų · H-bond donors 0 · H-bond acceptors 1
TPSA
3.9 Ų
H-bond donors
0
H-bond acceptors
1
Rotatable bonds
1
Heavy atoms
14

SMILES [2H]C([2H])([2H])[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]

Computed descriptors from PubChem (CID 16212321), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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