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Chemical structure of Lometrexol Sodium

GC66387

Lometrexol Sodium

Also listed as Lometrexol disodium

Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks· Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest· Lometrexol disodium has anticancer activity· Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor

ChemicalCAS120408-07-3MW487.42FormulaC21H23N5Na2O6
CAS number
120408-07-3
Molecular weight
487.42
Formula
C21H23N5Na2O6
InChIKey
SVJSWELRJWVPQD-KJWOGLQMSA-L
Catalogue number
GC66387
Brand
GLPBIO
Computed properties PubChem CID 135508134 · TPSA 189 Ų · H-bond donors 4 · H-bond acceptors 8
TPSA
189 Ų
H-bond donors
4
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
34

SMILES C1[C@H](CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

Computed descriptors from PubChem (CID 135508134), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.