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Chemical structure of Dynole 2-24

GC66056

Dynole 2-24

Also known as N-[[1-[3-(dimethylamino)propyl]indol-3-yl]methyl]decan-1-amine

Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0·56 μM for dynamin I)· Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1·9 μM)· Dynole 2-24 also shows 4·4-fold selectivity for dynamin I· Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis· CME: Clathrin mediated endocytosis

ChemicalCAS1416313-72-8MW371.6FormulaC24H41N3
CAS number
1416313-72-8
Molecular weight
371.6
Formula
C24H41N3
Solubility
DMSO ： ≥ 100 mg/mL (269·11 mM)
InChIKey
ZXKCYZJGHXORKJ-UHFFFAOYSA-N
Catalogue number
GC66056
Brand
GLPBIO
Computed properties PubChem CID 71546959 · XLogP 6.2 · TPSA 20.2 Ų · H-bond donors 1
XLogP
6.2
TPSA
20.2 Ų
H-bond donors
1
H-bond acceptors
2
Rotatable bonds
15
Heavy atoms
27

SMILES CCCCCCCCCCNCC1=CN(C2=CC=CC=C21)CCCN(C)C

Computed descriptors from PubChem (CID 71546959), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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