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Chemical structure of K67

GC66004

K67

Also known as 4-ethoxy-N-[4-[(4-ethoxyphenyl)sulfonylamino]-3-(2-oxopropyl)naphthalen-1-yl]benzenesulfonamide

K67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62· K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2· K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1

ChemicalCAS2046250-48-8MW582.69FormulaC29H30N2O7S2
CAS number
2046250-48-8
Molecular weight
582.69
Formula
C29H30N2O7S2
InChIKey
VUIVGOOWLHGDPZ-UHFFFAOYSA-N
Catalogue number
GC66004
Brand
GLPBIO
Computed properties PubChem CID 119057445 · XLogP 4.5 · TPSA 145 Ų · H-bond donors 2
XLogP
4.5
TPSA
145 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
12
Heavy atoms
40

SMILES CCOC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)NS(=O)(=O)C4=CC=C(C=C4)OCC)CC(=O)C

Computed descriptors from PubChem (CID 119057445), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.