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Chemical structure of Cathepsin C-IN-5

GC65998

Cathepsin C-IN-5

Also known as N-[3-[[5-chloro-2-[(5-thiophen-3-yl-2-pyridinyl)amino]pyrimidin-4-yl]amino]phenyl]acetamide

Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59·9 nM, 4·26 μM, >5 μM, >5 μM, >5 μM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively· Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood· Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases)· Cathepsin C-IN-5 shows anti-inflammatory activity

ChemicalCAS2825567-97-1MW436.92FormulaC21H17ClN6OS
CAS number
2825567-97-1
Molecular weight
436.92
Formula
C21H17ClN6OS
Solubility
DMSO ： 20 mg/mL (45·77 mM; ultrasonic and warming and heat to 60°C)
InChIKey
CVEIEBFUSJRUSP-UHFFFAOYSA-N
Catalogue number
GC65998
Brand
GLPBIO
Computed properties PubChem CID 163409160 · XLogP 4.3 · TPSA 120 Ų · H-bond donors 3
XLogP
4.3
TPSA
120 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
30

SMILES CC(=O)NC1=CC=CC(=C1)NC2=NC(=NC=C2Cl)NC3=NC=C(C=C3)C4=CSC=C4

Computed descriptors from PubChem (CID 163409160), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.