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Chemical structure of NB-360

GC65970

NB-360

Also known as N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide

NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM)· NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice· NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice· NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E

ChemicalCAS1262857-73-7MW449.4FormulaC21H19F4N5O2
CAS number
1262857-73-7
Molecular weight
449.4
Formula
C21H19F4N5O2
Solubility
DMSO ： 250 mg/mL (556·30 mM; Need ultrasonic)
InChIKey
BQFHTVUWPJXLOW-VQTJNVASSA-N
Catalogue number
GC65970
Brand
GLPBIO
Computed properties PubChem CID 66665322 · XLogP 2.2 · TPSA 113 Ų · H-bond donors 2
XLogP
2.2
TPSA
113 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
3
Heavy atoms
32

SMILES CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(CO[C@@](C(=N3)N)(C)C(F)(F)F)C)C#N

Computed descriptors from PubChem (CID 66665322), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.