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Chemical structure of Indimitecan

GC65939

Indimitecan

Also known as 20-(3-imidazol-1-ylpropyl)-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione

Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities

ChemicalCAS915360-05-3MW459.45FormulaC25H21N3O6
CAS number
915360-05-3
Molecular weight
459.45
Formula
C25H21N3O6
Solubility
DMSO : 8·33 mg/mL (18·13 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
InChIKey
GCILEJUNEYIABW-UHFFFAOYSA-N
Catalogue number
GC65939
Brand
GLPBIO
Computed properties PubChem CID 11519397 · XLogP 2.2 · TPSA 92.1 Ų · H-bond donors 0
XLogP
2.2
TPSA
92.1 Ų
H-bond donors
0
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
34

SMILES COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCN6C=CN=C6)OC

Computed descriptors from PubChem (CID 11519397), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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