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Chemical structure of INCB38579

GC65937

INCB38579

Also known as 1-[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydro-1H-isoquinolin-2-yl]-2-cyclopentylethanone

INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4·8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM)· INCB38579 shows anti-inflammatory pain and anti-pruritic activities

ChemicalCAS1246207-65-7MW434.58FormulaC25H34N6O
CAS number
1246207-65-7
Molecular weight
434.58
Formula
C25H34N6O
Solubility
DMSO ： 230 mg/mL (529·25 mM; ultrasonic and warming and heat to 60°C)
InChIKey
LZOCXAJJOQPLKB-UHFFFAOYSA-N
Catalogue number
GC65937
Brand
GLPBIO
Computed properties PubChem CID 59496762 · XLogP 3.2 · TPSA 78.6 Ų · H-bond donors 1
XLogP
3.2
TPSA
78.6 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
32

SMILES CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC4=C(CCN(C4)C(=O)CC5CCCC5)C=C3)N

Computed descriptors from PubChem (CID 59496762), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.