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Chemical structure of MASM7

GC65890

MASM7

Also known as 2-[2-[(5-cyclopropyl-4-phenyl-1,2,4-triazol-3-yl)sulfanyl]propanoylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins· MASM7 can increase Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN· MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1·1 μM

ChemicalCAS920868-45-7MW453.58FormulaC22H23N5O2S2
CAS number
920868-45-7
Molecular weight
453.58
Formula
C22H23N5O2S2
Solubility
DMSO ： 100 mg/mL (220·47 mM; Need ultrasonic)
InChIKey
MTAWXPCGCQTSOJ-UHFFFAOYSA-N
Catalogue number
GC65890
Brand
GLPBIO
Computed properties PubChem CID 16347380 · XLogP 3.9 · TPSA 156 Ų · H-bond donors 2
XLogP
3.9
TPSA
156 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
31

SMILES CC(C(=O)NC1=C(C2=C(S1)CCC2)C(=O)N)SC3=NN=C(N3C4=CC=CC=C4)C5CC5

Computed descriptors from PubChem (CID 16347380), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
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