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Chemical structure of INY-03-041

GC65559

INY-03-041

Also known as 3-[7-[10-[[(2S)-2-(4-chlorophenyl)-3-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-oxopropyl]amino]decyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide (Cereblon ligand)· INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2·0 nM, 6·8 nM and 3·5 nM, respectively

ChemicalCAS2503017-97-6MW798.41FormulaC44H56ClN7O5
CAS number
2503017-97-6
Molecular weight
798.41
Formula
C44H56ClN7O5
Solubility
DMSO ： 115 mg/mL (144·04 mM; ultrasonic and warming and heat to 80°C)
InChIKey
GQGZWBDNMCIYSF-OZDCPDTESA-N
Catalogue number
GC65559
Brand
GLPBIO
Computed properties PubChem CID 146014478 · XLogP 5.8 · TPSA 148 Ų · H-bond donors 3
XLogP
5.8
TPSA
148 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
17
Heavy atoms
57

SMILES C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNCCCCCCCCCCC4=C5CN(C(=O)C5=CC=C4)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)O

Computed descriptors from PubChem (CID 146014478), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.