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Chemical structure of FAP-2286

GC65537

FAP-2286

Also known as (5R,11S,17S,20S,23S,26S,29R)-23-(3-amino-3-oxopropyl)-26-benzyl-5-(hexanoylamino)-20-[(1R)-1-hydroxyethyl]-6,12,18,21,24,27-hexaoxo-35-[2-[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]ethylsulfanylmethyl]-3,31-dithia-7,13,19,22,25,28-hexazatetracyclo[31.3.1.07,11.013,17]heptatriaconta-1(37),33,35-triene-29-carboxylic acid

FAP-2286 is a potent and selective FAP-binding peptide conjugated to a radionuclide chelator with a mean IC50 value of 2·7 ± 0·9nM for inhibiting human FAP protease activity

ChemicalCAS2581741-18-4MW1470.77FormulaC67H99N13O18S3
CAS number
2581741-18-4
Molecular weight
1470.77
Formula
C67H99N13O18S3
Solubility
Water ： ≥ 100 mg/mL (67·99 mM)
InChIKey
UHKLVUPDBJFFBB-ZCDGVBLYSA-N
Catalogue number
GC65537
Brand
GLPBIO
Computed properties PubChem CID 163408889 · XLogP -8.1 · TPSA 517 Ų · H-bond donors 12
XLogP
-8.1
TPSA
517 Ų
H-bond donors
12
H-bond acceptors
25
Rotatable bonds
25
Heavy atoms
101

SMILES CCCCCC(=O)N[C@H]1CSCC2=CC(=CC(=C2)CSCCNC(=O)CN3CCN(CCN(CCN(CC3)CC(=O)O)CC(=O)O)CC(=O)O)CSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@@H]5CCCN5C1=O)[C@@H](C)O)CCC(=O)N)CC6=CC=CC=C6)C(=O)O

Computed descriptors from PubChem (CID 163408889), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.