GC65460
HDACs/mTOR Inhibitor 1
Also known as (2R)-N-[4-[1-[7-(hydroxyamino)-7-oxoheptyl]-4-morpholin-4-ylpyrazolo[5,4-d]pyrimidin-6-yl]phenyl]-2-methylmorpholine-4-carboxamide
HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0·19 nM, 1·8 nM, 1·2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively· HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo
- CAS number
- 2271413-06-8
- Molecular weight
- 566.65
- Formula
- C28H38N8O5
- Solubility
- DMSO ： 32·5 mg/mL (57·35 mM; Need ultrasonic)
- InChIKey
- YPXRCUVTZDXVHY-HXUWFJFHSA-N
- Catalogue number
- GC65460
- Brand
- GLPBIO
Computed properties PubChem CID 137628684 · XLogP 1.5 · TPSA 147 Ų · H-bond donors 3
- XLogP
- 1.5
- TPSA
- 147 Ų
- H-bond donors
- 3
- H-bond acceptors
- 9
- Rotatable bonds
- 10
- Heavy atoms
- 41
SMILES C[C@@H]1CN(CCO1)C(=O)NC2=CC=C(C=C2)C3=NC4=C(C=NN4CCCCCCC(=O)NO)C(=N3)N5CCOCC5
Computed descriptors from PubChem (CID 137628684), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il