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Chemical structure of UZH2

GC65437

UZH2

Also known as 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one

UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM

ChemicalCAS2756566-45-5MW513.63FormulaC27H37F2N7O
CAS number
2756566-45-5
Molecular weight
513.63
Formula
C27H37F2N7O
InChIKey
GYWOVBUGFWWSJR-UHFFFAOYSA-N
Catalogue number
GC65437
Brand
GLPBIO
Computed properties PubChem CID 156587343 · XLogP 4 · TPSA 76.6 Ų · H-bond donors 2
XLogP
4
TPSA
76.6 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
37

SMILES CC1(CCN(CC1)CC2=CC(=C(C=C2F)N3CC(=O)NC4(C3)CCN(CC4)C5=NC=NC(=C5)NC)F)C

Computed descriptors from PubChem (CID 156587343), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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