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Chemical structure of KHK-IN-2

GC65391

KHK-IN-2

Also known as 6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile

KHK-IN-2 is a highly potent and selective inhibitor of fructokinase (KHK) with an IC50 of 0·45μM

ChemicalCAS2135304-43-5MW372.34FormulaC16H19F3N4O3
CAS number
2135304-43-5
Molecular weight
372.34
Formula
C16H19F3N4O3
Solubility
DMSO ： 250 mg/mL (671·43 mM; Need ultrasonic)
InChIKey
FAXXYODRCHXHTQ-HUBLWGQQSA-N
Catalogue number
GC65391
Brand
GLPBIO
Computed properties PubChem CID 129900198 · XLogP 0.6 · TPSA 104 Ų · H-bond donors 3
XLogP
0.6
TPSA
104 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
2
Heavy atoms
26

SMILES C[C@@]1(CCN(C1)C2=C(C(=CC(=N2)N3C[C@@H]([C@H](C3)O)O)C(F)(F)F)C#N)O

Computed descriptors from PubChem (CID 129900198), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.