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Chemical structure of Envonalkib

GC65380

Envonalkib

Also known as 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[4-methoxy-6-[(2S)-2-methylpiperazin-1-yl]-3-pyridinyl]pyridin-2-amine

Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1·96 nM, 35·1 nM, and 61·3 nM for WT and mutated L1196M and G1269S-ALK· Envonalkib can be used for the research of non-small cell lung cancer

ChemicalCAS1621519-26-3MW506.4FormulaC24H26Cl2FN5O2
CAS number
1621519-26-3
Molecular weight
506.4
Formula
C24H26Cl2FN5O2
Solubility
DMSO ： 100 mg/mL (197·47 mM; Need ultrasonic)
InChIKey
BVGDAZBTIVRTGO-UONOGXRCSA-N
Catalogue number
GC65380
Brand
GLPBIO
Computed properties PubChem CID 76899983 · XLogP 4.5 · TPSA 85.5 Ų · H-bond donors 2
XLogP
4.5
TPSA
85.5 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
34

SMILES C[C@H]1CNCCN1C2=NC=C(C(=C2)OC)C3=CC(=C(N=C3)N)O[C@H](C)C4=C(C=CC(=C4Cl)F)Cl

Computed descriptors from PubChem (CID 76899983), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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