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Chemical structure of Borussertib

GC65367

Borussertib

Also known as N-[2-oxo-3-[1-[[4-(5-oxo-3-phenyl-6H-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-5-yl]prop-2-enamide

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0·8 nM and a Ki of 2·2 nM for Aktwt

ChemicalCAS1800070-77-2MW596.68FormulaC36H32N6O3
CAS number
1800070-77-2
Molecular weight
596.68
Formula
C36H32N6O3
Solubility
DMSO ： 25 mg/mL (41·90 mM; Need ultrasonic)
InChIKey
HXBRBOYWXDLHDC-UHFFFAOYSA-N
Catalogue number
GC65367
Brand
GLPBIO
Computed properties PubChem CID 122668091 · XLogP 4.3 · TPSA 107 Ų · H-bond donors 3
XLogP
4.3
TPSA
107 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
7
Heavy atoms
45

SMILES C=CC(=O)NC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)CC4=CC=C(C=C4)C5=C(C=C6C(=N5)C=CNC6=O)C7=CC=CC=C7

Computed descriptors from PubChem (CID 122668091), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.