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Chemical structure of TAS0728

GC65310

TAS0728

Also known as 4-amino-N-[4-[2-(dimethylamino)-2-oxoethyl]-2,3-dimethylphenyl]-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidine-3-carboxamide

TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC50 of 13 nM· TAS0728 also shows IC50s of 4·9, 8·5, 31, 65, 33, 25 and 86 nM for BMX、HER4、BLK、EGFR、JAK3、SLK and LOK respectively· Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2＜/b, HER3, and downstream effectors

ChemicalCAS2088323-16-2MW504.58FormulaC26H32N8O3
CAS number
2088323-16-2
Molecular weight
504.58
Formula
C26H32N8O3
Solubility
DMSO ： 125 mg/mL (247·73 mM; Need ultrasonic)
InChIKey
JCCIICHPRAAMGK-GOSISDBHSA-N
Catalogue number
GC65310
Brand
GLPBIO
Computed properties PubChem CID 130275856 · XLogP 1.7 · TPSA 139 Ų · H-bond donors 2
XLogP
1.7
TPSA
139 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
37

SMILES CC1=C(C=CC(=C1C)NC(=O)C2=NN(C3=NC=NC(=C23)N)[C@@H]4CCCN(C4)C(=O)C=C)CC(=O)N(C)C

Computed descriptors from PubChem (CID 130275856), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.