Loading...
Chemical structure of AB-680

GC65293

AB-680

Also known as [[(2R,3S,4R,5R)-5-[6-chloro-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]pyrazolo[5,4-b]pyridin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid

AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4·9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39· Anti-tumor activity

ChemicalCAS2105904-82-1MW580.82FormulaC20H24ClFN4O9P2
CAS number
2105904-82-1
Molecular weight
580.82
Formula
C20H24ClFN4O9P2
Solubility
DMSO ： 200 mg/mL (344·34 mM; Need ultrasonic)
InChIKey
MFYLCAMJNGIULC-KCVUFLITSA-N
Catalogue number
GC65293
Brand
GLPBIO
Computed properties PubChem CID 130205852 · XLogP -0.7 · TPSA 196 Ų · H-bond donors 6
XLogP
-0.7
TPSA
196 Ų
H-bond donors
6
H-bond acceptors
13
Rotatable bonds
9
Heavy atoms
37

SMILES C[C@@H](C1=CC=CC=C1F)NC2=CC(=NC3=C2C=NN3[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(CP(=O)(O)O)O)O)O)Cl

Computed descriptors from PubChem (CID 130205852), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.