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Chemical structure of Lotilaner

GC65292

Lotilaner

Also known as 3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide

Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23·84 nM for Drosophila melanogaster GABA receptor

ChemicalCAS1369852-71-0MW596.76FormulaC20H14Cl3F6N3O3S
CAS number
1369852-71-0
Molecular weight
596.76
Formula
C20H14Cl3F6N3O3S
Solubility
DMSO ： ≥ 100 mg/mL (167·57 mM)
InChIKey
HDKWFBCPLKNOCK-SFHVURJKSA-N
Catalogue number
GC65292
Brand
GLPBIO
Computed properties PubChem CID 76959255 · XLogP 6.6 · TPSA 108 Ų · H-bond donors 2
XLogP
6.6
TPSA
108 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
36

SMILES CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

Computed descriptors from PubChem (CID 76959255), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.