Loading...
Chemical structure of PCC0208017

GC65253

PCC0208017

Also known as 2-N-(2-methyl-3,4-dihydro-1H-isoquinolin-6-yl)-4-N-(1H-pyrazol-5-ylmethyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine

PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1·8 and 2·01?nM, respectively· PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31·4 and 33·7?nM, respectively· PCC0208017 suppresses glioma progression?in?vitro?and?in?vivo· PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis· PCC0208017 demonstrates robust antitumor activity?in?vivo?and displays good BBB permeability

ChemicalCAS2623158-64-3MW403.4FormulaC19H20F3N7
CAS number
2623158-64-3
Molecular weight
403.4
Formula
C19H20F3N7
Solubility
DMSO ： 125 mg/mL (309·87 mM; Need ultrasonic)
InChIKey
PIESSZHWYCPHQD-UHFFFAOYSA-N
Catalogue number
GC65253
Brand
GLPBIO
Computed properties PubChem CID 163321087 · XLogP 3 · TPSA 81.8 Ų · H-bond donors 3
XLogP
3
TPSA
81.8 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
29

SMILES CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCC4=CC=NN4)C(F)(F)F

Computed descriptors from PubChem (CID 163321087), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.