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Chemical structure of STL127705

GC65249

STL127705

Also known as 2-[2-(3,4-dimethoxyphenyl)ethylamino]-6-(3-fluorophenyl)-8H-pyrimido[4,5-d]pyrimidine-5,7-dione

STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3·5 μM· STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase· STL127705 shows antiproliferative and anticancer activity· STL127705 induces apoptosis

ChemicalCAS1326852-06-5MW437.42FormulaC22H20FN5O4
CAS number
1326852-06-5
Molecular weight
437.42
Formula
C22H20FN5O4
Solubility
Water ： 100 mg/mL (228·61 mM; Need ultrasonic)|DMSO ： 2·4 mg/mL (5·49 mM; Need ultrasonic)
InChIKey
FPVFCXYTLUJPQJ-UHFFFAOYSA-N
Catalogue number
GC65249
Brand
GLPBIO
Computed properties PubChem CID 53333307 · XLogP 3.1 · TPSA 106 Ų · H-bond donors 2
XLogP
3.1
TPSA
106 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
32

SMILES COC1=C(C=C(C=C1)CCNC2=NC=C3C(=N2)NC(=O)N(C3=O)C4=CC(=CC=C4)F)OC

Computed descriptors from PubChem (CID 53333307), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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