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Chemical structure of FGFR1/DDR2 inhibitor 1

GC65212

FGFR1/DDR2 inhibitor 1

Also known as 3-[3-(1-cyclopropylpyrazol-4-yl)-1H-indazol-6-yl]-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamide

FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31·1 nM and 3·2 nM, respectively· Antitumor activity

ChemicalCAS2308497-58-5MW501.5FormulaC28H22F3N5O
CAS number
2308497-58-5
Molecular weight
501.5
Formula
C28H22F3N5O
Solubility
DMSO ： 250 mg/mL (498·50 mM; Need ultrasonic)
InChIKey
ZEOWTGPWHLSLOG-UHFFFAOYSA-N
Catalogue number
GC65212
Brand
GLPBIO
Computed properties PubChem CID 138454761 · XLogP 5.7 · TPSA 75.6 Ų · H-bond donors 2
XLogP
5.7
TPSA
75.6 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
37

SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CC4=C(C=C3)C(=NN4)C5=CN(N=C5)C6CC6

Computed descriptors from PubChem (CID 138454761), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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