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Chemical structure of YS-370

GC65184

YS-370

Also known as 4-[3-[4-[1-[(2-bromophenyl)methyl]-2-phenylindol-3-yl]-7-methoxyquinazolin-6-yl]oxypropyl]morpholine

YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp)· YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4· YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells· YS-370 in combination with paclitaxel achieves much stronger antitumor activity

ChemicalCAS2470908-79-1MW663.6FormulaC37H35BrN4O3
CAS number
2470908-79-1
Molecular weight
663.6
Formula
C37H35BrN4O3
Solubility
DMSO ： 8·33 mg/mL (12·55 mM; ultrasonic and warming and heat to 80°C)
InChIKey
WSOJDUFWINGDJI-UHFFFAOYSA-N
Catalogue number
GC65184
Brand
GLPBIO
Computed properties PubChem CID 162679251 · XLogP 7.2 · TPSA 61.6 Ų · H-bond donors 0
XLogP
7.2
TPSA
61.6 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
10
Heavy atoms
45

SMILES COC1=C(C=C2C(=C1)N=CN=C2C3=C(N(C4=CC=CC=C43)CC5=CC=CC=C5Br)C6=CC=CC=C6)OCCCN7CCOCC7

Computed descriptors from PubChem (CID 162679251), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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