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Chemical structure of Glumetinib

GC64947

Glumetinib

Also known as 6-(1-methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonylpyrazolo[4,5-b]pyridine

Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC50 of 0·42 nM· Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3· Antitumor activity

ChemicalCAS1642581-63-2MW459.48FormulaC21H17N9O2S
CAS number
1642581-63-2
Molecular weight
459.48
Formula
C21H17N9O2S
Solubility
DMSO ： 41·67 mg/mL (90·69 mM; Need ultrasonic)
InChIKey
RYBLECYFLJXEJX-UHFFFAOYSA-N
Catalogue number
GC64947
Brand
GLPBIO
Computed properties PubChem CID 117797905 · XLogP 1.9 · TPSA 126 Ų · H-bond donors 0
XLogP
1.9
TPSA
126 Ų
H-bond donors
0
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
33

SMILES CN1C=C(C=N1)C2=CN3C(=NC=C3S(=O)(=O)N4C5=C(C=N4)N=CC(=C5)C6=CN(N=C6)C)C=C2

Computed descriptors from PubChem (CID 117797905), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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