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Chemical structure of CHDI-390576

GC64942

CHDI-390576

Also known as 2-(2-fluorophenyl)-N-hydroxy-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]acetamide

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform

ChemicalCAS1629729-98-1MW391.32FormulaC19H13F4N3O2
CAS number
1629729-98-1
Molecular weight
391.32
Formula
C19H13F4N3O2
Solubility
DMSO ： 250 mg/mL (638·86 mM; Need ultrasonic)
InChIKey
LMGDHGQJJLEAPQ-UHFFFAOYSA-N
Catalogue number
GC64942
Brand
GLPBIO
Computed properties PubChem CID 81689842 · XLogP 3.3 · TPSA 75.1 Ų · H-bond donors 2
XLogP
3.3
TPSA
75.1 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
28

SMILES C1=CC=C(C(=C1)C(C2=CC=C(C=C2)C3=NC=C(C=N3)C(F)(F)F)C(=O)NO)F

Computed descriptors from PubChem (CID 81689842), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.