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Chemical structure of PERK-IN-5

GC64866

PERK-IN-5

Also known as 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-propan-2-ylpyridine-3-carboxamide

PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively)· PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model

ChemicalCAS2616821-91-9MW468.5FormulaC25H26F2N4O3
CAS number
2616821-91-9
Molecular weight
468.5
Formula
C25H26F2N4O3
Solubility
DMSO ： 250 mg/mL (533·62 mM; Need ultrasonic)
InChIKey
YNDQMKBAYRFBMW-JOCHJYFZSA-N
Catalogue number
GC64866
Brand
GLPBIO
Computed properties PubChem CID 163196452 · XLogP 4 · TPSA 117 Ų · H-bond donors 4
XLogP
4
TPSA
117 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
34

SMILES CCC1=C(C=CC(=C1)NC(=O)[C@@H](C2=CC(=CC(=C2)F)F)O)C3=CC(=C(N=C3)N)C(=O)NC(C)C

Computed descriptors from PubChem (CID 163196452), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.