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Chemical structure of Famitinib

GC64836

Famitinib

Also known as 5-[2-(diethylamino)ethyl]-2-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-3-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one

Famitinib (SHR1020), an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFRβ with IC50 values of 2·3 nM, 4·7 nM and 6·6 nM, respectively· Famitinib exerts powerful antitumor activity in human gastric cancer cells and xenografts· Famitinib triggers apoptosis

ChemicalCAS1044040-56-3MW410.48FormulaC23H27FN4O2
CAS number
1044040-56-3
Molecular weight
410.48
Formula
C23H27FN4O2
InChIKey
GKEYKDOLBLYGRB-LGMDPLHJSA-N
Catalogue number
GC64836
Brand
GLPBIO
Computed properties PubChem CID 16662431 · XLogP 2.5 · TPSA 68.4 Ų · H-bond donors 2
XLogP
2.5
TPSA
68.4 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
30

SMILES CCN(CC)CCN1CCC2=C(C1=O)C(=C(N2)/C=C\3/C4=C(C=CC(=C4)F)NC3=O)C

Computed descriptors from PubChem (CID 16662431), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.