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Chemical structure of Garsorasib

GC64723

Garsorasib

Also known as 7-(2-amino-6-fluorophenyl)-1-(4,6-dicyclopropylpyrimidin-5-yl)-4-[(2S,5R)-2,5-dimethyl-4-prop-2-enoylpiperazin-1-yl]-6-fluoropyrido[2,3-d]pyrimidin-2-one

Garsorasib is a potent inhibitor of KRAS G12C with an IC50 of 10 nM· Garsorasib has the potential for the research of various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (non-small cell lung cancer) (extracted from patent WO2020233592A1, compound 2)

ChemicalCAS2559761-14-5MW598.65FormulaC32H32F2N8O2
CAS number
2559761-14-5
Molecular weight
598.65
Formula
C32H32F2N8O2
InChIKey
DKFRWZJCNPETGI-SJORKVTESA-N
Catalogue number
GC64723
Brand
GLPBIO
Computed properties PubChem CID 155332312 · XLogP 3.1 · TPSA 121 Ų · H-bond donors 1
XLogP
3.1
TPSA
121 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
44

SMILES C[C@@H]1CN([C@H](CN1C(=O)C=C)C)C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)N)C5=C(N=CN=C5C6CC6)C7CC7

Computed descriptors from PubChem (CID 155332312), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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