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Chemical structure of NCT-58

GC64714

NCT-58

Also known as 5-methoxy-N-[3-methoxy-4-(2-piperidin-2-ylethoxy)phenyl]-2,2-dimethylchromene-6-carboxamide

NCT-58 is a potent inhibitor of C-terminal HSP90· NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation· NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells· NCT-58 induces apoptosis in HER2-positive breast cancer cells

ChemicalCAS2411429-33-7MW466.57FormulaC27H34N2O5
CAS number
2411429-33-7
Molecular weight
466.57
Formula
C27H34N2O5
Solubility
DMSO ： 50 mg/mL (107·17 mM; Need ultrasonic)
InChIKey
QGEKYFVMAGLOKW-UHFFFAOYSA-N
Catalogue number
GC64714
Brand
GLPBIO
Computed properties PubChem CID 149033485 · XLogP 4.4 · TPSA 78.1 Ų · H-bond donors 2
XLogP
4.4
TPSA
78.1 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
8
Heavy atoms
34

SMILES CC1(C=CC2=C(O1)C=CC(=C2OC)C(=O)NC3=CC(=C(C=C3)OCCC4CCCCN4)OC)C

Computed descriptors from PubChem (CID 149033485), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.