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Chemical structure of Povorcitinib

GC64701

Povorcitinib

Also known as 4-[3-(cyanomethyl)-3-[4-(3,5-dimethyl-1H-pyrazol-4-yl)pyrazol-1-yl]azetidin-1-yl]-2,5-difluoro-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzamide

Povorcitinib is a potent and selective inhibitor of JAK1

ChemicalCAS1637677-22-5MW507.46FormulaC23H22F5N7O
CAS number
1637677-22-5
Molecular weight
507.46
Formula
C23H22F5N7O
Solubility
DMSO ： 250 mg/mL (492·65 mM; Need ultrasonic)
InChIKey
MSGYSFWCPOBHEV-AWEZNQCLSA-N
Catalogue number
GC64701
Brand
GLPBIO
Computed properties PubChem CID 86280672 · XLogP 3.1 · TPSA 103 Ų · H-bond donors 2
XLogP
3.1
TPSA
103 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
36

SMILES CC1=C(C(=NN1)C)C2=CN(N=C2)C3(CN(C3)C4=C(C=C(C(=C4)F)C(=O)N[C@@H](C)C(F)(F)F)F)CC#N

Computed descriptors from PubChem (CID 86280672), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.